{"id":4021,"date":"2026-09-05T17:33:38","date_gmt":"2026-09-05T14:33:38","guid":{"rendered":"https:\/\/wniss.com\/?p=4021"},"modified":"2026-09-05T17:34:39","modified_gmt":"2026-09-05T14:34:39","slug":"comprehensive-all-antidepressants-list-by-primary-family","status":"publish","type":"post","link":"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/","title":{"rendered":"Comprehensive All Antidepressants List by Primary Family"},"content":{"rendered":"\n<div class=\"markdown prose dark:prose-invert wrap-break-word w-full light markdown-new-styling\"><h2><span class=\"ez-toc-section\" id=\"Comprehensive_All_Antidepressants_List_by_Primary_Family\"><\/span>Comprehensive All Antidepressants List by Primary Family<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Quick_Answer\"><\/span>Quick Answer<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Antidepressants are grouped into several primary medication families based on how they affect brain chemicals such as serotonin, norepinephrine, and dopamine. Selective Serotonin Reuptake Inhibitors (SSRIs) are usually the first-line treatment for depression because they balance effectiveness and safety. Other families, including SNRIs, atypical antidepressants, tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), serotonin modulators, NMDA receptor antagonists, and newer combination therapies, may be recommended depending on symptoms, medical history, side effects, and previous treatment response.<\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Comprehensive_All_Antidepressants_List_by_Primary_Family\" >Comprehensive All Antidepressants List by Primary Family<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Quick_Answer\" >Quick Answer<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Why_Antidepressants_Are_Classified_Into_Families\" >Why Antidepressants Are Classified Into Families<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Selective_Serotonin_Reuptake_Inhibitors_SSRIs\" >Selective Serotonin Reuptake Inhibitors (SSRIs)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Common_SSRIs\" >Common SSRIs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Advantages\" >Advantages<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Possible_Side_Effects\" >Possible Side Effects<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Serotonin-Norepinephrine_Reuptake_Inhibitors_SNRIs\" >Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Common_SNRIs\" >Common SNRIs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Benefits\" >Benefits<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Norepinephrine-Dopamine_Reuptake_Inhibitors_NDRIs\" >Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Main_Medication\" >Main Medication<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Unique_Benefits\" >Unique Benefits<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Possible_Drawbacks\" >Possible Drawbacks<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Noradrenergic_and_Specific_Serotonergic_Antidepressants_NaSSA\" >Noradrenergic and Specific Serotonergic Antidepressants (NaSSA)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Main_Medication-2\" >Main Medication<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Advantages-2\" >Advantages<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Common_Side_Effects\" >Common Side Effects<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Serotonin_Modulators_and_Stimulators\" >Serotonin Modulators and Stimulators<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Common_Medications\" >Common Medications<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Potential_Benefits\" >Potential Benefits<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Tricyclic_Antidepressants_TCAs\" >Tricyclic Antidepressants (TCAs)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Common_TCAs\" >Common TCAs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Clinical_Uses\" >Clinical Uses<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Limitations\" >Limitations<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Monoamine_Oxidase_Inhibitors_MAOIs\" >Monoamine Oxidase Inhibitors (MAOIs)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Available_MAOIs\" >Available MAOIs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Important_Considerations\" >Important Considerations<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#NMDA_Receptor_Antagonists\" >NMDA Receptor Antagonists<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Medication\" >Medication<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Approved_Use\" >Approved Use<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Newer_Combination_Therapies\" >Newer Combination Therapies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Comparing_the_Main_Antidepressant_Families\" >Comparing the Main Antidepressant Families<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#How_Doctors_Choose_an_Antidepressant\" >How Doctors Choose an Antidepressant<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Safety_Considerations\" >Safety Considerations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Internal_Linking_Opportunities\" >Internal Linking Opportunities<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Frequently_Asked_Questions\" >Frequently Asked Questions<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#What_is_the_most_commonly_prescribed_antidepressant_family\" >What is the most commonly prescribed antidepressant family?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Which_antidepressants_usually_cause_the_fewest_sexual_side_effects\" >Which antidepressants usually cause the fewest sexual side effects?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Are_older_antidepressants_still_prescribed\" >Are older antidepressants still prescribed?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#How_long_do_antidepressants_take_to_work\" >How long do antidepressants take to work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Can_antidepressants_be_stopped_suddenly\" >Can antidepressants be stopped suddenly?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/wniss.com\/en-gb\/comprehensive-all-antidepressants-list-by-primary-family\/#Source\" >Source<\/a><\/li><\/ul><\/nav><\/div>\n\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Antidepressant Family<\/th><th class=\"last:pe-10\">Primary Mechanism<\/th><th class=\"last:pe-10\">Common Examples<\/th><th class=\"last:pe-10\">Typical Uses<\/th><\/tr><\/thead><tbody><tr><td>SSRIs<\/td><td>Increase serotonin<\/td><td>Sertraline, Fluoxetine, Escitalopram, Paroxetine, Citalopram, Fluvoxamine<\/td><td>Major depression, anxiety disorders, OCD, PTSD<\/td><\/tr><tr><td>SNRIs<\/td><td>Increase serotonin and norepinephrine<\/td><td>Venlafaxine, Desvenlafaxine, Duloxetine, Levomilnacipran, Milnacipran<\/td><td>Depression, anxiety, chronic pain<\/td><\/tr><tr><td>NDRIs<\/td><td>Increase norepinephrine and dopamine<\/td><td>Bupropion<\/td><td>Depression, seasonal affective disorder, smoking cessation<\/td><\/tr><tr><td>NaSSA<\/td><td>Increase norepinephrine and serotonin indirectly<\/td><td>Mirtazapine<\/td><td>Depression with insomnia or poor appetite<\/td><\/tr><tr><td>Serotonin Modulators<\/td><td>Affect serotonin receptors and reuptake<\/td><td>Trazodone, Nefazodone, Vilazodone, Vortioxetine<\/td><td>Depression, sleep problems<\/td><\/tr><tr><td>TCAs<\/td><td>Block serotonin and norepinephrine reuptake<\/td><td>Amitriptyline, Nortriptyline, Imipramine, Clomipramine, Desipramine, Doxepin<\/td><td>Depression, chronic pain, migraine prevention<\/td><\/tr><tr><td>MAOIs<\/td><td>Block monoamine oxidase enzyme<\/td><td>Phenelzine, Tranylcypromine, Isocarboxazid, Selegiline Patch<\/td><td>Treatment-resistant depression<\/td><\/tr><tr><td>NMDA Antagonists<\/td><td>Enhance glutamate signaling<\/td><td>Esketamine<\/td><td>Treatment-resistant depression<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 48.7969px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-91b3a79f.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Why_Antidepressants_Are_Classified_Into_Families\"><\/span>Why Antidepressants Are Classified Into Families<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Grouping antidepressants into medication families helps healthcare professionals predict:<\/p>\n<ul>\n<li>\n<p>How each medication works<\/p>\n<\/li>\n<li>\n<p>Expected benefits<\/p>\n<\/li>\n<li>\n<p>Common side effects<\/p>\n<\/li>\n<li>\n<p>Drug interactions<\/p>\n<\/li>\n<li>\n<p>Appropriate patient selection<\/p>\n<\/li>\n<\/ul>\n<p>Although medications within the same family share similar mechanisms, each drug has unique characteristics.<\/p>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Selective_Serotonin_Reuptake_Inhibitors_SSRIs\"><\/span>Selective Serotonin Reuptake Inhibitors (SSRIs)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>SSRIs remain the most commonly prescribed antidepressants worldwide.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Common_SSRIs\"><\/span>Common SSRIs<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Sertraline (Zoloft)<\/p>\n<\/li>\n<li>\n<p>Fluoxetine (Prozac)<\/p>\n<\/li>\n<li>\n<p>Escitalopram (Lexapro)<\/p>\n<\/li>\n<li>\n<p>Citalopram (Celexa)<\/p>\n<\/li>\n<li>\n<p>Paroxetine (Paxil)<\/p>\n<\/li>\n<li>\n<p>Fluvoxamine (Luvox)<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Advantages\"><\/span>Advantages<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Good safety profile<\/p>\n<\/li>\n<li>\n<p>Effective for anxiety disorders<\/p>\n<\/li>\n<li>\n<p>Lower overdose risk<\/p>\n<\/li>\n<li>\n<p>Well studied<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Possible_Side_Effects\"><\/span>Possible Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Nausea<\/p>\n<\/li>\n<li>\n<p>Headache<\/p>\n<\/li>\n<li>\n<p>Sexual dysfunction<\/p>\n<\/li>\n<li>\n<p>Sleep changes<\/p>\n<\/li>\n<li>\n<p>Temporary increase in anxiety during early treatment<\/p>\n<\/li>\n<\/ul>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Serotonin-Norepinephrine_Reuptake_Inhibitors_SNRIs\"><\/span>Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>SNRIs increase both serotonin and norepinephrine.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Common_SNRIs\"><\/span>Common SNRIs<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Venlafaxine<\/p>\n<\/li>\n<li>\n<p>Desvenlafaxine<\/p>\n<\/li>\n<li>\n<p>Duloxetine<\/p>\n<\/li>\n<li>\n<p>Levomilnacipran<\/p>\n<\/li>\n<li>\n<p>Milnacipran (primarily approved for fibromyalgia in some countries)<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Benefits\"><\/span>Benefits<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>They may be particularly useful for patients with:<\/p>\n<ul>\n<li>\n<p>Depression<\/p>\n<\/li>\n<li>\n<p>Generalized anxiety disorder<\/p>\n<\/li>\n<li>\n<p>Diabetic neuropathy<\/p>\n<\/li>\n<li>\n<p>Fibromyalgia<\/p>\n<\/li>\n<li>\n<p>Chronic musculoskeletal pain<\/p>\n<\/li>\n<\/ul>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Norepinephrine-Dopamine_Reuptake_Inhibitors_NDRIs\"><\/span>Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Main_Medication\"><\/span>Main Medication<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Bupropion (Wellbutrin)<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Unique_Benefits\"><\/span>Unique Benefits<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Minimal sexual side effects<\/p>\n<\/li>\n<li>\n<p>May improve energy<\/p>\n<\/li>\n<li>\n<p>Can support smoking cessation<\/p>\n<\/li>\n<li>\n<p>Less likely to cause weight gain<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Possible_Drawbacks\"><\/span>Possible Drawbacks<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>May increase anxiety in some people<\/p>\n<\/li>\n<li>\n<p>Not suitable for individuals with seizure disorders<\/p>\n<\/li>\n<\/ul>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Noradrenergic_and_Specific_Serotonergic_Antidepressants_NaSSA\"><\/span>Noradrenergic and Specific Serotonergic Antidepressants (NaSSA)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Main_Medication-2\"><\/span>Main Medication<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Mirtazapine (Remeron)<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Advantages-2\"><\/span>Advantages<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Improves sleep<\/p>\n<\/li>\n<li>\n<p>May increase appetite<\/p>\n<\/li>\n<li>\n<p>Helpful for weight loss related to depression<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Common_Side_Effects\"><\/span>Common Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Drowsiness<\/p>\n<\/li>\n<li>\n<p>Weight gain<\/p>\n<\/li>\n<li>\n<p>Increased appetite<\/p>\n<\/li>\n<\/ul>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Serotonin_Modulators_and_Stimulators\"><\/span>Serotonin Modulators and Stimulators<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>These medications work differently from traditional SSRIs.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Common_Medications\"><\/span>Common Medications<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Trazodone<\/p>\n<\/li>\n<li>\n<p>Vilazodone<\/p>\n<\/li>\n<li>\n<p>Vortioxetine<\/p>\n<\/li>\n<li>\n<p>Nefazodone<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Potential_Benefits\"><\/span>Potential Benefits<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Improved cognitive symptoms<\/p>\n<\/li>\n<li>\n<p>Better sleep (especially trazodone)<\/p>\n<\/li>\n<li>\n<p>Lower rates of certain SSRI side effects in some patients<\/p>\n<\/li>\n<\/ul>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Tricyclic_Antidepressants_TCAs\"><\/span>Tricyclic Antidepressants (TCAs)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>TCAs were among the earliest antidepressants developed.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Common_TCAs\"><\/span>Common TCAs<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Amitriptyline<\/p>\n<\/li>\n<li>\n<p>Nortriptyline<\/p>\n<\/li>\n<li>\n<p>Imipramine<\/p>\n<\/li>\n<li>\n<p>Clomipramine<\/p>\n<\/li>\n<li>\n<p>Desipramine<\/p>\n<\/li>\n<li>\n<p>Doxepin<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Clinical_Uses\"><\/span>Clinical Uses<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Besides depression, TCAs are prescribed for:<\/p>\n<ul>\n<li>\n<p>Neuropathic pain<\/p>\n<\/li>\n<li>\n<p>Migraine prevention<\/p>\n<\/li>\n<li>\n<p>Insomnia<\/p>\n<\/li>\n<li>\n<p>OCD (Clomipramine)<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Limitations\"><\/span>Limitations<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Dry mouth<\/p>\n<\/li>\n<li>\n<p>Constipation<\/p>\n<\/li>\n<li>\n<p>Dizziness<\/p>\n<\/li>\n<li>\n<p>Cardiac effects<\/p>\n<\/li>\n<li>\n<p>Greater overdose risk<\/p>\n<\/li>\n<\/ul>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Monoamine_Oxidase_Inhibitors_MAOIs\"><\/span>Monoamine Oxidase Inhibitors (MAOIs)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Although used less often today, MAOIs remain valuable for some individuals with treatment-resistant depression.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Available_MAOIs\"><\/span>Available MAOIs<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Phenelzine<\/p>\n<\/li>\n<li>\n<p>Tranylcypromine<\/p>\n<\/li>\n<li>\n<p>Isocarboxazid<\/p>\n<\/li>\n<li>\n<p>Selegiline Transdermal Patch<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Important_Considerations\"><\/span>Important Considerations<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Patients must follow dietary restrictions because certain foods high in tyramine can cause dangerous increases in blood pressure.<\/p>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"NMDA_Receptor_Antagonists\"><\/span>NMDA Receptor Antagonists<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>This newer class targets glutamate instead of monoamines.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Medication\"><\/span>Medication<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Esketamine Nasal Spray<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Approved_Use\"><\/span>Approved Use<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>\n<p>Treatment-resistant depression<\/p>\n<\/li>\n<li>\n<p>Depression with acute suicidal symptoms (under supervised care in some settings)<\/p>\n<\/li>\n<\/ul>\n<p>Administration occurs only in certified healthcare facilities because monitoring is required.<\/p>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Newer_Combination_Therapies\"><\/span>Newer Combination Therapies<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Some recently approved medications combine multiple mechanisms.<\/p>\n<p>Examples include:<\/p>\n<ul>\n<li>\n<p>Dextromethorphan-Bupropion<\/p>\n<\/li>\n<li>\n<p>Fixed-dose combinations approved in selected countries<\/p>\n<\/li>\n<\/ul>\n<p>These medications may work faster for some patients, although long-term research continues.<\/p>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Comparing_the_Main_Antidepressant_Families\"><\/span>Comparing the Main Antidepressant Families<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Family<\/th><th class=\"last:pe-10\">First-Line<\/th><th class=\"last:pe-10\">Anxiety<\/th><th class=\"last:pe-10\">Sleep<\/th><th class=\"last:pe-10\">Weight Gain<\/th><th class=\"last:pe-10\">Sexual Side Effects<\/th><\/tr><\/thead><tbody><tr><td>SSRIs<\/td><td>Yes<\/td><td>Excellent<\/td><td>Neutral<\/td><td>Low<\/td><td>Common<\/td><\/tr><tr><td>SNRIs<\/td><td>Yes<\/td><td>Excellent<\/td><td>Neutral<\/td><td>Low<\/td><td>Common<\/td><\/tr><tr><td>NDRI<\/td><td>Sometimes<\/td><td>Moderate<\/td><td>May increase alertness<\/td><td>Low<\/td><td>Rare<\/td><\/tr><tr><td>NaSSA<\/td><td>Sometimes<\/td><td>Good<\/td><td>Excellent<\/td><td>Higher<\/td><td>Less common<\/td><\/tr><tr><td>TCAs<\/td><td>No<\/td><td>Good<\/td><td>Good<\/td><td>Moderate<\/td><td>Moderate<\/td><\/tr><tr><td>MAOIs<\/td><td>No<\/td><td>Good<\/td><td>Variable<\/td><td>Variable<\/td><td>Variable<\/td><\/tr><tr><td>NMDA Antagonists<\/td><td>Specialized<\/td><td>Limited<\/td><td>Neutral<\/td><td>Minimal<\/td><td>Minimal<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 64.7969px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-91b3a79f.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"How_Doctors_Choose_an_Antidepressant\"><\/span>How Doctors Choose an Antidepressant<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Several factors influence medication selection:<\/p>\n<ul>\n<li>\n<p>Previous response<\/p>\n<\/li>\n<li>\n<p>Family history of medication success<\/p>\n<\/li>\n<li>\n<p>Anxiety symptoms<\/p>\n<\/li>\n<li>\n<p>Sleep quality<\/p>\n<\/li>\n<li>\n<p>Appetite changes<\/p>\n<\/li>\n<li>\n<p>Chronic pain<\/p>\n<\/li>\n<li>\n<p>Other medical conditions<\/p>\n<\/li>\n<li>\n<p>Current medications<\/p>\n<\/li>\n<li>\n<p>Pregnancy or breastfeeding considerations<\/p>\n<\/li>\n<li>\n<p>Potential drug interactions<\/p>\n<\/li>\n<\/ul>\n<p>There is no single antidepressant that is best for everyone.<\/p>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Safety_Considerations\"><\/span>Safety Considerations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Antidepressants should always be used under medical supervision.<\/p>\n<p>Patients should:<\/p>\n<ul>\n<li>\n<p>Take medications exactly as prescribed.<\/p>\n<\/li>\n<li>\n<p>Avoid stopping suddenly without guidance.<\/p>\n<\/li>\n<li>\n<p>Report unusual mood changes immediately.<\/p>\n<\/li>\n<li>\n<p>Attend regular follow-up appointments.<\/p>\n<\/li>\n<li>\n<p>Inform healthcare providers about all other medications and supplements.<\/p>\n<\/li>\n<\/ul>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Internal_Linking_Opportunities\"><\/span>Internal Linking Opportunities<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Consider linking naturally to:<\/p>\n<ul>\n<li>\n<p>Depression symptoms overview: <span class=\"decorated-link\">https:\/\/wniss.com\/en-gb\/depression\/<span aria-hidden=\"true\" class=\"ms-0.5 inline-block align-middle leading-none select-none\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"block h-[0.75em] w-[0.75em] stroke-current stroke-[0.75] select-none\"><use href=\"\/cdn\/assets\/sprites-core-91b3a79f.svg#304883\" fill=\"currentColor\"><\/use><\/svg><\/span><\/span><\/p>\n<\/li>\n<li>\n<p>Depression education and related articles: <span class=\"decorated-link\">https:\/\/wniss.com\/en-gb\/category\/depression\/<span aria-hidden=\"true\" class=\"ms-0.5 inline-block align-middle leading-none select-none\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"block h-[0.75em] w-[0.75em] stroke-current stroke-[0.75] select-none\"><use href=\"\/cdn\/assets\/sprites-core-91b3a79f.svg#304883\" fill=\"currentColor\"><\/use><\/svg><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Frequently_Asked_Questions\"><\/span>Frequently Asked Questions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"What_is_the_most_commonly_prescribed_antidepressant_family\"><\/span>What is the most commonly prescribed antidepressant family?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>SSRIs are generally the most commonly prescribed first-line antidepressants because they offer a favorable balance of effectiveness, safety, and tolerability.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Which_antidepressants_usually_cause_the_fewest_sexual_side_effects\"><\/span>Which antidepressants usually cause the fewest sexual side effects?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Bupropion is commonly associated with a lower risk of sexual side effects compared with many SSRIs and SNRIs, though individual responses vary.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Are_older_antidepressants_still_prescribed\"><\/span>Are older antidepressants still prescribed?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Yes. TCAs and MAOIs are still used for certain patients, particularly when newer medications have not been effective or when specific symptoms make them appropriate.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_long_do_antidepressants_take_to_work\"><\/span>How long do antidepressants take to work?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Many people begin noticing improvement within 2 to 4 weeks, but the full therapeutic effect often takes 6 to 8 weeks or longer.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Can_antidepressants_be_stopped_suddenly\"><\/span>Can antidepressants be stopped suddenly?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>No. Many antidepressants should be tapered gradually under medical supervision to reduce the risk of withdrawal symptoms and relapse.<\/p>\n<hr>\n<h2><span class=\"ez-toc-section\" id=\"Source\"><\/span>Source<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"decorated-link\">https:\/\/en.wikipedia.org\/wiki\/Depression_(mood)<span aria-hidden=\"true\" class=\"ms-0.5 inline-block align-middle leading-none select-none\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"block h-[0.75em] w-[0.75em] stroke-current stroke-[0.75] select-none\"><use href=\"\/cdn\/assets\/sprites-core-91b3a79f.svg#304883\" fill=\"currentColor\"><\/use><\/svg><\/span><\/span><\/p>\n<hr>\n<p><strong>Medical Disclaimer<\/strong><\/p>\n<p>The information in this article is intended for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Never use this information to diagnose or treat a medical condition on your own. Always consult a qualified physician or healthcare provider before starting, stopping, or changing any medication or treatment plan.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Comprehensive All Antidepressants List by Primary Family Quick Answer Antidepressants are grouped into several primary medication families based on how they affect brain chemicals such as serotonin, norepinephrine, and dopamine. Selective Serotonin Reuptake Inhibitors (SSRIs) are usually the first-line treatment for depression because they balance effectiveness and safety. Other families, including SNRIs, atypical antidepressants, tricyclic&#8230;<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[730],"tags":[],"class_list":["post-4021","post","type-post","status-publish","format-standard","hentry","category-depression"],"acf":[],"_links":{"self":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4021","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/comments?post=4021"}],"version-history":[{"count":2,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4021\/revisions"}],"predecessor-version":[{"id":5778,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4021\/revisions\/5778"}],"wp:attachment":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/media?parent=4021"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/categories?post=4021"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/tags?post=4021"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}