{"id":4073,"date":"2026-09-05T17:33:05","date_gmt":"2026-09-05T14:33:05","guid":{"rendered":"https:\/\/wniss.com\/?p=4073"},"modified":"2026-09-05T17:34:07","modified_gmt":"2026-09-05T14:34:07","slug":"esketamine-nasal-spray-for-treatment-resistant-cases","status":"publish","type":"post","link":"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/","title":{"rendered":"Esketamine Nasal Spray for Treatment Resistant Cases"},"content":{"rendered":"\n<div class=\"markdown prose dark:prose-invert wrap-break-word w-full light markdown-new-styling\"><h2><span class=\"ez-toc-section\" id=\"Esketamine_Nasal_Spray_for_Treatment_Resistant_Depression_How_It_Works_and_Who_May_Benefit\"><\/span>Esketamine Nasal Spray for Treatment Resistant Depression: How It Works and Who May Benefit<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>Esketamine nasal spray<\/strong> is an advanced treatment option designed for adults with <strong>treatment-resistant depression (TRD)<\/strong>, especially when standard antidepressant medications have not provided enough relief. It works differently from traditional antidepressants by targeting the brain\u2019s glutamate system and may produce faster symptom improvement in some patients. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 109px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Esketamine_Nasal_Spray_for_Treatment_Resistant_Depression_How_It_Works_and_Who_May_Benefit\" >Esketamine Nasal Spray for Treatment Resistant Depression: How It Works and Who May Benefit<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#What_Is_Esketamine_Nasal_Spray\" >What Is Esketamine Nasal Spray?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#How_Esketamine_Helps_Treatment_Resistant_Depression\" >How Esketamine Helps Treatment Resistant Depression<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Who_May_Be_a_Candidate_for_Esketamine_Nasal_Spray\" >Who May Be a Candidate for Esketamine Nasal Spray?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#How_Esketamine_Nasal_Spray_Treatment_Is_Given\" >How Esketamine Nasal Spray Treatment Is Given<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Benefits_of_Esketamine_for_Resistant_Depression\" >Benefits of Esketamine for Resistant Depression<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Rapid_Symptom_Improvement\" >Rapid Symptom Improvement<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Option_After_Failed_Antidepressants\" >Option After Failed Antidepressants<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Potential_Reduction_in_Relapse_Risk\" >Potential Reduction in Relapse Risk<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Esketamine_Nasal_Spray_Side_Effects\" >Esketamine Nasal Spray Side Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Safety_Considerations_Before_Starting_Treatment\" >Safety Considerations Before Starting Treatment<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Esketamine_Compared_With_Traditional_Depression_Treatments\" >Esketamine Compared With Traditional Depression Treatments<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#The_Role_of_Medical_Supervision\" >The Role of Medical Supervision<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Frequently_Asked_Questions_About_Esketamine_Nasal_Spray\" >Frequently Asked Questions About Esketamine Nasal Spray<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Is_esketamine_nasal_spray_a_cure_for_depression\" >Is esketamine nasal spray a cure for depression?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#How_quickly_does_esketamine_work\" >How quickly does esketamine work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Can_anyone_with_depression_use_esketamine\" >Can anyone with depression use esketamine?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Does_esketamine_replace_antidepressant_medication\" >Does esketamine replace antidepressant medication?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#What_happens_after_taking_an_esketamine_dose\" >What happens after taking an esketamine dose?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Medical_Disclaimer\" >Medical Disclaimer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/wniss.com\/en-gb\/esketamine-nasal-spray-for-treatment-resistant-cases\/#Source_Reference\" >Source Reference<\/a><\/li><\/ul><\/nav><\/div>\n\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Topic<\/th><th class=\"last:pe-10\">Key Information<\/th><\/tr><\/thead><tbody><tr><td>Treatment name<\/td><td>Esketamine nasal spray<\/td><\/tr><tr><td>Main use<\/td><td>Treatment-resistant depression (TRD)<\/td><\/tr><tr><td>Drug class<\/td><td>NMDA receptor antagonist<\/td><\/tr><tr><td>Administration<\/td><td>Nasal spray under healthcare supervision<\/td><\/tr><tr><td>Typical use<\/td><td>Combined with an oral antidepressant<\/td><\/tr><tr><td>Potential benefit<\/td><td>Faster reduction of depressive symptoms in some patients<\/td><\/tr><tr><td>Common effects<\/td><td>Dizziness, nausea, sedation, dissociation<\/td><\/tr><tr><td>Monitoring<\/td><td>Medical observation after each dose<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 33px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_Is_Esketamine_Nasal_Spray\"><\/span>What Is Esketamine Nasal Spray?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Esketamine nasal spray is a prescription medication derived from ketamine, developed specifically as a medical treatment for certain severe depressive conditions. Unlike many conventional antidepressants that mainly influence serotonin or norepinephrine, esketamine affects the glutamate pathway through NMDA receptor activity. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 92px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<p>Doctors may consider esketamine when a person has <strong>treatment-resistant depression<\/strong>, meaning symptoms have not improved adequately after trying multiple antidepressant treatments. It is generally used alongside an oral antidepressant rather than as a replacement for all other depression care. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 101px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PMC<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_Esketamine_Helps_Treatment_Resistant_Depression\"><\/span>How Esketamine Helps Treatment Resistant Depression<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Traditional antidepressants often require several weeks before noticeable improvement occurs. Esketamine has a different mechanism that influences brain communication pathways associated with mood regulation, emotional processing, and neural connections.<\/p>\n<p>Research suggests that esketamine may increase activity related to glutamate signaling and support synaptic plasticity, which may contribute to its rapid antidepressant effects. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 56px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">Nature<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<p>For some individuals with severe depression, this faster action can be important, particularly when symptoms are persistent or significantly affecting daily functioning.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Who_May_Be_a_Candidate_for_Esketamine_Nasal_Spray\"><\/span>Who May Be a Candidate for Esketamine Nasal Spray?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Esketamine is not usually considered a first treatment choice for mild depression. It is mainly evaluated for adults who meet criteria for treatment-resistant depression.<\/p>\n<p>A healthcare provider may consider it when:<\/p>\n<ul>\n<li>\n<p>Depression symptoms remain after adequate antidepressant trials.<\/p>\n<\/li>\n<li>\n<p>Multiple medications have provided limited improvement.<\/p>\n<\/li>\n<li>\n<p>Symptoms significantly affect work, relationships, or daily activities.<\/p>\n<\/li>\n<li>\n<p>Other treatment approaches require additional support.<\/p>\n<\/li>\n<\/ul>\n<p>Clinical guidelines commonly require evidence that previous antidepressant treatments were unsuccessful before considering esketamine therapy. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 72px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">NICE<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_Esketamine_Nasal_Spray_Treatment_Is_Given\"><\/span>How Esketamine Nasal Spray Treatment Is Given<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Esketamine is administered through a nasal spray device in a certified medical setting. Patients typically receive the medication under supervision because temporary effects can occur after dosing.<\/p>\n<p>A common treatment schedule includes:<\/p>\n<ul>\n<li>\n<p>More frequent sessions during the initial treatment phase.<\/p>\n<\/li>\n<li>\n<p>Reduced frequency during continuation or maintenance periods.<\/p>\n<\/li>\n<li>\n<p>Ongoing evaluation of symptom improvement and side effects. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<p>Patients are usually monitored after administration before leaving the healthcare facility.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Benefits_of_Esketamine_for_Resistant_Depression\"><\/span>Benefits of Esketamine for Resistant Depression<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Rapid_Symptom_Improvement\"><\/span>Rapid Symptom Improvement<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>One of the main advantages of esketamine is its relatively rapid onset compared with many traditional antidepressants. Some patients experience improvement within a shorter timeframe, although responses vary between individuals. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 56px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">Nature<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Option_After_Failed_Antidepressants\"><\/span>Option After Failed Antidepressants<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>For people who have tried several antidepressant medications without adequate results, esketamine provides another therapeutic pathway.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Potential_Reduction_in_Relapse_Risk\"><\/span>Potential Reduction in Relapse Risk<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Research has shown that continued esketamine treatment combined with an oral antidepressant may help maintain improvement and delay relapse in some patients with treatment-resistant depression. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 99px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">JAMA Network<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Esketamine_Nasal_Spray_Side_Effects\"><\/span>Esketamine Nasal Spray Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Like all medications, esketamine can cause side effects. Common reactions include:<\/p>\n<ul>\n<li>\n<p>Dissociation or feeling disconnected from surroundings<\/p>\n<\/li>\n<li>\n<p>Dizziness<\/p>\n<\/li>\n<li>\n<p>Nausea<\/p>\n<\/li>\n<li>\n<p>Sleepiness or sedation<\/p>\n<\/li>\n<li>\n<p>Increased blood pressure temporarily<\/p>\n<\/li>\n<li>\n<p>Unusual sensations or altered perception<\/p>\n<\/li>\n<\/ul>\n<p>These effects are often monitored because they can appear shortly after administration. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 92px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Safety_Considerations_Before_Starting_Treatment\"><\/span>Safety Considerations Before Starting Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Before beginning esketamine therapy, doctors usually review:<\/p>\n<ul>\n<li>\n<p>Current medications<\/p>\n<\/li>\n<li>\n<p>History of substance misuse<\/p>\n<\/li>\n<li>\n<p>Cardiovascular health<\/p>\n<\/li>\n<li>\n<p>Blood pressure concerns<\/p>\n<\/li>\n<li>\n<p>Mental health history<\/p>\n<\/li>\n<\/ul>\n<p>Because esketamine affects brain activity and perception, supervised medical administration is an important part of safe treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Esketamine_Compared_With_Traditional_Depression_Treatments\"><\/span>Esketamine Compared With Traditional Depression Treatments<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Esketamine does not replace established treatments such as psychotherapy, lifestyle support, or conventional antidepressants. Instead, it is considered an additional option for specific cases.<\/p>\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Treatment<\/th><th class=\"last:pe-10\">Main Action<\/th><th class=\"last:pe-10\">Typical Use<\/th><\/tr><\/thead><tbody><tr><td>SSRIs<\/td><td>Increase serotonin availability<\/td><td>Common first-line depression treatment<\/td><\/tr><tr><td>SNRIs<\/td><td>Affect serotonin and norepinephrine<\/td><td>Depression and anxiety disorders<\/td><\/tr><tr><td>Psychotherapy<\/td><td>Changes thinking and behavioral patterns<\/td><td>Mild to severe depression support<\/td><\/tr><tr><td>Esketamine<\/td><td>Targets NMDA\/glutamate pathways<\/td><td>Treatment-resistant cases<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 33px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<p>A comprehensive treatment plan may combine medication approaches with psychotherapy and ongoing mental health support.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_Role_of_Medical_Supervision\"><\/span>The Role of Medical Supervision<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Esketamine treatment requires careful monitoring because patients may experience temporary changes in perception, alertness, or coordination after receiving a dose.<\/p>\n<p>Healthcare professionals evaluate:<\/p>\n<ul>\n<li>\n<p>Depression symptom changes<\/p>\n<\/li>\n<li>\n<p>Side effects<\/p>\n<\/li>\n<li>\n<p>Treatment response<\/p>\n<\/li>\n<li>\n<p>Need for continued sessions<\/p>\n<\/li>\n<\/ul>\n<p>This structured approach helps balance potential benefits with safety considerations.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Frequently_Asked_Questions_About_Esketamine_Nasal_Spray\"><\/span>Frequently Asked Questions About Esketamine Nasal Spray<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Is_esketamine_nasal_spray_a_cure_for_depression\"><\/span>Is esketamine nasal spray a cure for depression?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Esketamine is not considered a permanent cure for depression. It is a treatment option that may reduce symptoms and help some people achieve improvement when combined with other depression care strategies.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_quickly_does_esketamine_work\"><\/span>How quickly does esketamine work?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Some patients notice symptom changes faster than with traditional antidepressants, but response time varies. Doctors evaluate effectiveness throughout the treatment process. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 56px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">Nature<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Can_anyone_with_depression_use_esketamine\"><\/span>Can anyone with depression use esketamine?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>No. Esketamine is generally reserved for specific adults with treatment-resistant depression or other approved indications evaluated by healthcare professionals. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Does_esketamine_replace_antidepressant_medication\"><\/span>Does esketamine replace antidepressant medication?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Usually, esketamine is used together with an oral antidepressant rather than replacing all other depression treatments. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 47px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PMC<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_happens_after_taking_an_esketamine_dose\"><\/span>What happens after taking an esketamine dose?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Patients may experience temporary dizziness, sedation, or altered perception. Medical monitoring is required after administration to ensure safety. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Medical_Disclaimer\"><\/span>Medical Disclaimer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The information in this article is provided for educational and awareness purposes only and does not replace advice from a qualified doctor or licensed healthcare provider. Do not use this information to diagnose, treat, or change medication plans for any medical condition. Always consult a healthcare professional before starting, stopping, or modifying any treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Source_Reference\"><\/span>Source Reference<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Source link: <span class=\"decorated-link\">https:\/\/en.wikipedia.org\/wiki\/Esketamine<span aria-hidden=\"true\" class=\"ms-0.5 inline-block align-middle leading-none select-none\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"block h-[0.75em] w-[0.75em] stroke-current stroke-[0.75] select-none\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#304883\" fill=\"currentColor\"><\/use><\/svg><\/span><\/span><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Esketamine Nasal Spray for Treatment Resistant Depression: How It Works and Who May Benefit Esketamine nasal spray is an advanced treatment option [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[730],"tags":[],"class_list":["post-4073","post","type-post","status-publish","format-standard","hentry","category-depression"],"acf":[],"_links":{"self":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4073","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/comments?post=4073"}],"version-history":[{"count":2,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4073\/revisions"}],"predecessor-version":[{"id":5857,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4073\/revisions\/5857"}],"wp:attachment":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/media?parent=4073"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/categories?post=4073"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/tags?post=4073"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}