{"id":4077,"date":"2026-09-05T17:33:02","date_gmt":"2026-09-05T14:33:02","guid":{"rendered":"https:\/\/wniss.com\/?p=4077"},"modified":"2026-09-05T17:34:04","modified_gmt":"2026-09-05T14:34:04","slug":"evaluating-best-medication-for-severe-depression-mdd","status":"publish","type":"post","link":"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/","title":{"rendered":"Evaluating Best Medication for Severe Depression MDD"},"content":{"rendered":"\n<div class=\"markdown prose dark:prose-invert wrap-break-word w-full light markdown-new-styling\"><h2><span class=\"ez-toc-section\" id=\"Evaluating_Best_Medication_for_Severe_Depression_MDD\"><\/span>Evaluating Best Medication for Severe Depression (MDD)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The <strong>best medication for severe depression (Major Depressive Disorder, MDD)<\/strong> depends on individual factors such as symptom pattern, previous treatment response, side effects, other health conditions, and whether symptoms include anxiety, insomnia, suicidal thoughts, psychotic features, or bipolar-related symptoms. There is no single antidepressant that works best for everyone, but several medication classes have strong evidence for treating severe depression.<\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Evaluating_Best_Medication_for_Severe_Depression_MDD\" >Evaluating Best Medication for Severe Depression (MDD)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Common_First-Line_Medications_for_Severe_Depression\" >Common First-Line Medications for Severe Depression<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#SSRIs_Often_the_Starting_Choice\" >SSRIs: Often the Starting Choice<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Sertraline\" >Sertraline<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Escitalopram\" >Escitalopram<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#SNRIs_for_Depression_With_Anxiety_or_Physical_Symptoms\" >SNRIs for Depression With Anxiety or Physical Symptoms<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Venlafaxine\" >Venlafaxine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Duloxetine\" >Duloxetine<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Medications_Sometimes_Used_for_Treatment-Resistant_Severe_Depression\" >Medications Sometimes Used for Treatment-Resistant Severe Depression<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Adding_an_Antipsychotic_Medication\" >Adding an Antipsychotic Medication<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Other_Advanced_Treatments\" >Other Advanced Treatments<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Choosing_Medication_Based_on_Depression_Symptoms\" >Choosing Medication Based on Depression Symptoms<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Severe_Depression_With_Anxiety\" >Severe Depression With Anxiety<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Severe_Depression_With_Insomnia_and_Appetite_Loss\" >Severe Depression With Insomnia and Appetite Loss<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Severe_Depression_With_Low_Energy_and_Fatigue\" >Severe Depression With Low Energy and Fatigue<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Severe_Depression_With_Suicidal_Thoughts\" >Severe Depression With Suicidal Thoughts<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#How_Long_Does_Depression_Medication_Take_to_Work\" >How Long Does Depression Medication Take to Work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Important_Factors_Before_Starting_Medication\" >Important Factors Before Starting Medication<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Combining_Medication_With_Therapy\" >Combining Medication With Therapy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-best-medication-for-severe-depression-mdd\/#Key_Takeaway\" >Key Takeaway<\/a><\/li><\/ul><\/nav><\/div>\n\n<h3><span class=\"ez-toc-section\" id=\"Common_First-Line_Medications_for_Severe_Depression\"><\/span>Common First-Line Medications for Severe Depression<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Medication Class<\/th><th class=\"last:pe-10\">Examples<\/th><th class=\"last:pe-10\">Potential Benefits<\/th><th class=\"last:pe-10\">Common Considerations<\/th><\/tr><\/thead><tbody><tr><td>SSRIs (Selective Serotonin Reuptake Inhibitors)<\/td><td>Sertraline, Escitalopram, Fluoxetine, Paroxetine<\/td><td>Often effective, generally well tolerated<\/td><td>May cause nausea, sleep changes, sexual side effects<\/td><\/tr><tr><td>SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors)<\/td><td>Venlafaxine, Duloxetine<\/td><td>May help depression with anxiety or pain symptoms<\/td><td>Can affect blood pressure in some people<\/td><\/tr><tr><td>Atypical Antidepressants<\/td><td>Bupropion, Mirtazapine<\/td><td>Useful for specific symptom patterns<\/td><td>Different side-effect profiles<\/td><\/tr><tr><td>Tricyclic Antidepressants (TCAs)<\/td><td>Amitriptyline, Nortriptyline<\/td><td>Effective for treatment-resistant depression<\/td><td>More side effects and safety concerns<\/td><\/tr><tr><td>MAOIs<\/td><td>Phenelzine, Tranylcypromine<\/td><td>Sometimes effective in difficult cases<\/td><td>Require dietary and medication precautions<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 48.8906px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"SSRIs_Often_the_Starting_Choice\"><\/span>SSRIs: Often the Starting Choice<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>SSRIs are commonly selected as initial treatment options because they combine effectiveness with a relatively favorable safety profile.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Sertraline\"><\/span>Sertraline<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">Zoloft<\/span><\/span> (sertraline) is frequently used for major depression, especially when depression occurs alongside anxiety symptoms.<\/p>\n<p>Possible advantages:<\/p>\n<ul>\n<li>\n<p>Strong research support<\/p>\n<\/li>\n<li>\n<p>Effective for depression and anxiety disorders<\/p>\n<\/li>\n<li>\n<p>Often suitable for long-term treatment<\/p>\n<\/li>\n<\/ul>\n<p>Possible disadvantages:<\/p>\n<ul>\n<li>\n<p>Sexual side effects<\/p>\n<\/li>\n<li>\n<p>Gastrointestinal symptoms<\/p>\n<\/li>\n<li>\n<p>Temporary increase in anxiety during early treatment for some people<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Escitalopram\"><\/span>Escitalopram<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">Lexapro<\/span><\/span> (escitalopram) is another commonly prescribed SSRI.<\/p>\n<p>It may be considered when patients need:<\/p>\n<ul>\n<li>\n<p>Good tolerability<\/p>\n<\/li>\n<li>\n<p>Relief from depressive symptoms and anxiety<\/p>\n<\/li>\n<li>\n<p>A simple dosing schedule<\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"SNRIs_for_Depression_With_Anxiety_or_Physical_Symptoms\"><\/span>SNRIs for Depression With Anxiety or Physical Symptoms<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>SNRIs increase serotonin and norepinephrine activity, which may be helpful when depression includes fatigue, low energy, or chronic pain symptoms.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Venlafaxine\"><\/span>Venlafaxine<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">Venlafaxine<\/span><\/span> may provide strong antidepressant effects, particularly at higher doses, but requires medical monitoring because some people experience increased blood pressure.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Duloxetine\"><\/span>Duloxetine<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">Duloxetine<\/span><\/span> can be useful when depression occurs with conditions involving nerve pain or chronic physical discomfort.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Medications_Sometimes_Used_for_Treatment-Resistant_Severe_Depression\"><\/span>Medications Sometimes Used for Treatment-Resistant Severe Depression<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>When someone does not respond adequately to standard antidepressants, psychiatrists may consider other strategies.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Adding_an_Antipsychotic_Medication\"><\/span>Adding an Antipsychotic Medication<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Certain atypical antipsychotics may be approved as add-on treatments for resistant depression, including:<\/p>\n<ul>\n<li>\n<p><span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">Aripiprazole<\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">Quetiapine<\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span class=\"hover:entity-accent entity-underline inline cursor-pointer align-baseline\"><span class=\"whitespace-normal\">Brexpiprazole<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<p>These medications require careful monitoring because they may cause weight changes, metabolic effects, sedation, or movement-related side effects.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Other_Advanced_Treatments\"><\/span>Other Advanced Treatments<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>For severe depression that does not improve with several treatments, specialists may evaluate options such as:<\/p>\n<ul>\n<li>\n<p>Electroconvulsive therapy (ECT)<\/p>\n<\/li>\n<li>\n<p>Transcranial magnetic stimulation (TMS)<\/p>\n<\/li>\n<li>\n<p>Ketamine-based treatments in appropriate clinical settings<\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Choosing_Medication_Based_on_Depression_Symptoms\"><\/span>Choosing Medication Based on Depression Symptoms<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Different symptom patterns may influence medication selection:<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Severe_Depression_With_Anxiety\"><\/span>Severe Depression With Anxiety<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Doctors may consider SSRIs or SNRIs because many also treat anxiety symptoms.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Severe_Depression_With_Insomnia_and_Appetite_Loss\"><\/span>Severe Depression With Insomnia and Appetite Loss<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Some medications with sedating effects, such as mirtazapine, may be considered.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Severe_Depression_With_Low_Energy_and_Fatigue\"><\/span>Severe Depression With Low Energy and Fatigue<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Bupropion or activating antidepressants may be considered in suitable patients.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Severe_Depression_With_Suicidal_Thoughts\"><\/span>Severe Depression With Suicidal Thoughts<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Urgent professional evaluation is important. Medication choice may involve closer monitoring, additional support, and sometimes faster-acting interventions.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_Long_Does_Depression_Medication_Take_to_Work\"><\/span>How Long Does Depression Medication Take to Work?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Antidepressants usually do not provide immediate relief.<\/p>\n<p>Typical timeline:<\/p>\n<ul>\n<li>\n<p><strong>1\u20132 weeks:<\/strong> Some early changes may appear, such as improved sleep or appetite.<\/p>\n<\/li>\n<li>\n<p><strong>4\u20138 weeks:<\/strong> Many people notice clearer improvement in mood and motivation.<\/p>\n<\/li>\n<li>\n<p><strong>Several months:<\/strong> Continued treatment may be needed to reduce relapse risk.<\/p>\n<\/li>\n<\/ul>\n<p>The dose and medication should only be adjusted with guidance from a qualified healthcare professional.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Important_Factors_Before_Starting_Medication\"><\/span>Important Factors Before Starting Medication<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>A clinician usually evaluates:<\/p>\n<ul>\n<li>\n<p>History of previous depression episodes<\/p>\n<\/li>\n<li>\n<p>Possible bipolar disorder symptoms<\/p>\n<\/li>\n<li>\n<p>Current medications and supplements<\/p>\n<\/li>\n<li>\n<p>Medical conditions<\/p>\n<\/li>\n<li>\n<p>Substance use<\/p>\n<\/li>\n<li>\n<p>Suicide risk<\/p>\n<\/li>\n<li>\n<p>Personal treatment preferences<\/p>\n<\/li>\n<\/ul>\n<p>Misdiagnosing bipolar depression as unipolar depression can lead to inappropriate treatment, so screening for past episodes of mania or hypomania is important.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Combining_Medication_With_Therapy\"><\/span>Combining Medication With Therapy<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Medication often works best when combined with evidence-based psychotherapy, especially for severe or recurring depression.<\/p>\n<p>Common therapies include:<\/p>\n<ul>\n<li>\n<p>Cognitive Behavioral Therapy (CBT)<\/p>\n<\/li>\n<li>\n<p>Interpersonal Therapy (IPT)<\/p>\n<\/li>\n<li>\n<p>Behavioral activation<\/p>\n<\/li>\n<li>\n<p>Structured lifestyle interventions<\/p>\n<\/li>\n<\/ul>\n<p>Medication can help regulate biological symptoms, while therapy can address thought patterns, coping skills, and relapse prevention.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Key_Takeaway\"><\/span>Key Takeaway<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The <strong>best medication for severe depression (MDD)<\/strong> is not one universal drug. SSRIs such as sertraline and escitalopram are common starting options because of their effectiveness and safety profile, while SNRIs, atypical antidepressants, augmentation strategies, and advanced treatments may be considered depending on individual needs. Treatment decisions should always be made with a mental health professional who can evaluate the full clinical picture.<\/p>\n<p><strong>Medical Disclaimer:<\/strong><br>\nThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Do not start, stop, or change any medication without consulting a qualified healthcare provider. If you or someone you know is experiencing thoughts of self-harm or suicide, seek urgent medical support or emergency assistance immediately.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Evaluating Best Medication for Severe Depression (MDD) The best medication for severe depression (Major Depressive Disorder, MDD) depends on individual factors such as symptom pattern, previous treatment response, side effects, other health conditions, and whether symptoms include anxiety, insomnia, suicidal thoughts, psychotic features, or bipolar-related symptoms. There is no single antidepressant that works best for&#8230;<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[730],"tags":[],"class_list":["post-4077","post","type-post","status-publish","format-standard","hentry","category-depression"],"acf":[],"_links":{"self":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/comments?post=4077"}],"version-history":[{"count":2,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4077\/revisions"}],"predecessor-version":[{"id":5861,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4077\/revisions\/5861"}],"wp:attachment":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/media?parent=4077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/categories?post=4077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/tags?post=4077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}