{"id":4097,"date":"2026-09-05T17:32:50","date_gmt":"2026-09-05T14:32:50","guid":{"rendered":"https:\/\/wniss.com\/?p=4097"},"modified":"2026-09-05T17:33:51","modified_gmt":"2026-09-05T14:33:51","slug":"evaluating-saffron-supplement-for-depression-clinical-data","status":"publish","type":"post","link":"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/","title":{"rendered":"Evaluating Saffron Supplement for Depression Clinical Data"},"content":{"rendered":"<figure class=\"wch-inserted-image\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-1024x683.webp\" alt=\"Evaluating Saffron Supplement for Depression Clinical Data - Evaluating Saffron Supplement for Depression\" loading=\"lazy\" class=\"wp-image-5881\" title=\"\" srcset=\"https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-1024x683.webp 1024w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-300x200.webp 300w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-150x100.webp 150w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-100x67.webp 100w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-200x133.webp 200w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-250x167.webp 250w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-350x233.webp 350w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-400x267.webp 400w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-500x333.webp 500w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z-600x400.webp 600w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/evaluating-saffron-supplement-for-depression-clinical-data-3-BGfE4z.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<div class=\"markdown prose dark:prose-invert wrap-break-word w-full light markdown-new-styling\"><h2><span class=\"ez-toc-section\" id=\"Quick_Answer\"><\/span>Quick Answer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Current clinical evidence suggests that <strong>saffron (Crocus sativus) supplements may reduce symptoms of mild to moderate depression<\/strong>, with several randomized controlled trials and meta-analyses finding benefits compared with placebo. Some studies also found saffron produced symptom improvements similar to standard antidepressants in selected patients. However, the evidence remains limited by relatively small studies, short follow-up periods, and concentration of research in a few geographic regions. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/#Quick_Answer\" >Quick Answer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/#What_the_Clinical_Data_Shows\" >What the Clinical Data Shows<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/#Strengths_of_the_Evidence\" >Strengths of the Evidence<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/#Important_Limitations\" >Important Limitations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/#Typical_Dosages_Studied\" >Typical Dosages Studied<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/#Possible_Mechanisms\" >Possible Mechanisms<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/#Safety_Considerations\" >Safety Considerations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/wniss.com\/en-gb\/evaluating-saffron-supplement-for-depression-clinical-data\/#Bottom_Line\" >Bottom Line<\/a><\/li><\/ul><\/nav><\/div>\n\n<h2><span class=\"ez-toc-section\" id=\"What_the_Clinical_Data_Shows\"><\/span>What the Clinical Data Shows<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Several systematic reviews have evaluated randomized controlled trials of saffron supplementation.<\/p>\n<p>Key findings include:<\/p>\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Outcome<\/th><th class=\"last:pe-10\">Evidence<\/th><\/tr><\/thead><tbody><tr><td>Compared with placebo<\/td><td>Significant improvement in depressive symptoms in adults with mild to moderate depression. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/td><\/tr><tr><td>Compared with antidepressants<\/td><td>Similar effectiveness to medications such as fluoxetine or imipramine in several short-term trials, although studies were generally small. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 62px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PMC<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/td><\/tr><tr><td>Safety<\/td><td>Most trials reported mild adverse effects, with no major increase in side effects compared with placebo or antidepressants. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 62px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 32.7969px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Strengths_of_the_Evidence\"><\/span>Strengths of the Evidence<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Clinical research on saffron has several encouraging features:<\/p>\n<ul>\n<li>\n<p>Multiple randomized, double-blind clinical trials<\/p>\n<\/li>\n<li>\n<p>Meta-analyses combining data from numerous studies<\/p>\n<\/li>\n<li>\n<p>Consistent improvement across several depression rating scales<\/p>\n<\/li>\n<li>\n<p>Good short-term tolerability<\/p>\n<\/li>\n<\/ul>\n<p>These findings make saffron one of the more extensively studied herbal supplements for depression. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Important_Limitations\"><\/span>Important Limitations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The evidence is promising but not definitive.<\/p>\n<p>Researchers consistently note that:<\/p>\n<ul>\n<li>\n<p>Most studies lasted only <strong>6\u201312 weeks<\/strong>.<\/p>\n<\/li>\n<li>\n<p>Sample sizes were relatively small.<\/p>\n<\/li>\n<li>\n<p>Many trials were conducted by the same research groups.<\/p>\n<\/li>\n<li>\n<p>More independent, multicenter studies are needed.<\/p>\n<\/li>\n<li>\n<p>Long-term effectiveness and safety remain uncertain. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 62px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PMC<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Typical_Dosages_Studied\"><\/span>Typical Dosages Studied<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Many clinical trials have evaluated:<\/p>\n<ul>\n<li>\n<p><strong>30 mg\/day<\/strong> of standardized saffron extract (commonly divided into two 15 mg doses)<\/p>\n<\/li>\n<\/ul>\n<p>Different commercial products are not necessarily equivalent because concentrations of active compounds (such as crocin and safranal) vary. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Possible_Mechanisms\"><\/span>Possible Mechanisms<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Researchers believe saffron may work through several biological pathways, including:<\/p>\n<ul>\n<li>\n<p>Modulation of serotonin signaling<\/p>\n<\/li>\n<li>\n<p>Antioxidant activity<\/p>\n<\/li>\n<li>\n<p>Anti-inflammatory effects<\/p>\n<\/li>\n<li>\n<p>Possible influence on dopamine and norepinephrine pathways<\/p>\n<\/li>\n<\/ul>\n<p>These mechanisms are still being investigated and are not completely understood. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 62px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PMC<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Safety_Considerations\"><\/span>Safety Considerations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Saffron supplements are generally well tolerated in clinical trials, but they are <strong>not appropriate for everyone<\/strong>.<\/p>\n<p>Use caution if you:<\/p>\n<ul>\n<li>\n<p>Take antidepressants or other medications affecting serotonin.<\/p>\n<\/li>\n<li>\n<p>Use blood-thinning medications.<\/p>\n<\/li>\n<li>\n<p>Are pregnant or breastfeeding.<\/p>\n<\/li>\n<li>\n<p>Have significant medical conditions requiring specialist care.<\/p>\n<\/li>\n<\/ul>\n<p>Because dietary supplements are regulated differently from prescription medications, product quality can vary between manufacturers. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 105px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">Verywell Health<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Bottom_Line\"><\/span>Bottom Line<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The current clinical evidence supports saffron as a <strong>promising adjunct or alternative option for some adults with mild to moderate depression<\/strong>, particularly when supervised by a healthcare professional. It should <strong>not replace evidence-based treatment<\/strong> for moderate to severe depression or for individuals experiencing suicidal thoughts or psychotic symptoms. Larger, longer, independently conducted trials are still needed before saffron can be considered a standard treatment. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+2<\/span><\/span><span class=\"flex h-4 w-full items-center justify-between absolute\" style=\"opacity: 0; transform: translateX(10%);\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PMC<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+2<\/span><\/span><\/span><\/span><\/span><\/span><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Quick Answer Current clinical evidence suggests that saffron (Crocus sativus) supplements may reduce symptoms of mild to moderate depression, with several randomized [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":5881,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[730],"tags":[],"class_list":["post-4097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-depression"],"acf":[],"_links":{"self":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/comments?post=4097"}],"version-history":[{"count":2,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4097\/revisions"}],"predecessor-version":[{"id":5882,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4097\/revisions\/5882"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/media\/5881"}],"wp:attachment":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/media?parent=4097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/categories?post=4097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/tags?post=4097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}