{"id":4119,"date":"2026-09-05T17:32:36","date_gmt":"2026-09-05T14:32:36","guid":{"rendered":"https:\/\/wniss.com\/?p=4119"},"modified":"2026-09-05T17:33:36","modified_gmt":"2026-09-05T14:33:36","slug":"how-nasal-spray-for-depression-works-in-fast-action-care","status":"publish","type":"post","link":"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/","title":{"rendered":"How Nasal Spray for Depression Works in Fast Action Care"},"content":{"rendered":"\n<div class=\"markdown prose dark:prose-invert wrap-break-word w-full light markdown-new-styling\"><h2><span class=\"ez-toc-section\" id=\"Nasal_Spray_for_Depression_How_Fast-Action_Care_Works\"><\/span>Nasal Spray for Depression: How Fast-Action Care Works<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><strong>Nasal spray for depression<\/strong> refers mainly to <strong>esketamine nasal spray<\/strong>, a prescription treatment designed for certain adults with <strong>treatment-resistant depression (TRD)<\/strong> and, in some cases, major depressive disorder with acute suicidal thoughts when used under medical supervision. Unlike traditional antidepressants that often take weeks, esketamine works through the brain\u2019s glutamate system and may produce noticeable changes more rapidly. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 116px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Nasal_Spray_for_Depression_How_Fast-Action_Care_Works\" >Nasal Spray for Depression: How Fast-Action Care Works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#How_Nasal_Spray_for_Depression_Works_in_the_Brain\" >How Nasal Spray for Depression Works in the Brain<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Why_Esketamine_Can_Act_Faster_Than_Standard_Antidepressants\" >Why Esketamine Can Act Faster Than Standard Antidepressants<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Who_May_Benefit_From_Depression_Nasal_Spray_Treatment\" >Who May Benefit From Depression Nasal Spray Treatment?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#What_Happens_During_a_Treatment_Session\" >What Happens During a Treatment Session?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Possible_Benefits_of_Fast-Acting_Depression_Nasal_Spray\" >Possible Benefits of Fast-Acting Depression Nasal Spray<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Rapid_symptom_improvement\" >Rapid symptom improvement<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#A_different_treatment_pathway\" >A different treatment pathway<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Option_for_difficult-to-treat_depression\" >Option for difficult-to-treat depression<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Side_Effects_and_Safety_Considerations\" >Side Effects and Safety Considerations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Nasal_Spray_for_Depression_Compared_With_Traditional_Antidepressants\" >Nasal Spray for Depression Compared With Traditional Antidepressants<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/wniss.com\/en-gb\/how-nasal-spray-for-depression-works-in-fast-action-care\/#Important_Medical_Considerations\" >Important Medical Considerations<\/a><\/li><\/ul><\/nav><\/div>\n\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Feature<\/th><th class=\"last:pe-10\">Details<\/th><\/tr><\/thead><tbody><tr><td>Active medication<\/td><td>Esketamine<\/td><\/tr><tr><td>Delivery method<\/td><td>Intranasal spray<\/td><\/tr><tr><td>Main target<\/td><td>NMDA receptors and glutamate pathways<\/td><\/tr><tr><td>Typical candidates<\/td><td>Adults with treatment-resistant depression<\/td><\/tr><tr><td>Speed of action<\/td><td>Effects may begin within hours to days for some patients<\/td><\/tr><tr><td>Administration<\/td><td>Given in a certified medical setting with monitoring<\/td><\/tr><tr><td>Common short-term effects<\/td><td>Dizziness, sedation, dissociation, increased blood pressure<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 32.8906px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"How_Nasal_Spray_for_Depression_Works_in_the_Brain\"><\/span>How Nasal Spray for Depression Works in the Brain<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Traditional antidepressants often focus on neurotransmitters such as serotonin and norepinephrine. Esketamine takes a different approach by affecting the <strong>glutamate system<\/strong>, one of the brain\u2019s major communication networks. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 101px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">\u0627\u0644\u0645\u0643\u062a\u0628\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u0637\u0628<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<p>After the spray is absorbed through the nasal lining, esketamine enters the bloodstream quickly and reaches the brain. It blocks <strong>NMDA receptors<\/strong>, which influences glutamate activity and activates pathways involved in brain-cell communication and flexibility. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 62px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<p>Researchers believe this process increases activity at <strong>AMPA receptors<\/strong> and stimulates pathways related to proteins such as <strong>BDNF (brain-derived neurotrophic factor)<\/strong>, which may support the rebuilding and strengthening of neural connections involved in mood regulation. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 101px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">\u0627\u0644\u0645\u0643\u062a\u0628\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u0637\u0628<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Why_Esketamine_Can_Act_Faster_Than_Standard_Antidepressants\"><\/span>Why Esketamine Can Act Faster Than Standard Antidepressants<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Many common antidepressants require several weeks because they gradually change receptor sensitivity and brain chemistry. Esketamine produces a more immediate effect by rapidly modifying glutamate signaling and synaptic activity. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 101px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">\u0627\u0644\u0645\u0643\u062a\u0628\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u0637\u0628<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<p>The nasal route also contributes to faster absorption. Studies report that intranasal esketamine reaches peak blood concentrations relatively quickly, often within approximately 20\u201340 minutes after administration. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 101px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">\u0627\u0644\u0645\u0643\u062a\u0628\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u0637\u0628<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<p>However, fast action does not mean it works instantly for everyone. Response varies depending on depression severity, previous treatments, overall health, and individual brain chemistry.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Who_May_Benefit_From_Depression_Nasal_Spray_Treatment\"><\/span>Who May Benefit From Depression Nasal Spray Treatment?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Esketamine nasal spray is generally considered for people who:<\/p>\n<ul>\n<li>\n<p>Have <strong>treatment-resistant depression<\/strong>, meaning symptoms have not improved adequately after trying appropriate antidepressant treatments.<\/p>\n<\/li>\n<li>\n<p>Need another option after limited response to conventional medications.<\/p>\n<\/li>\n<li>\n<p>Are experiencing severe depressive symptoms requiring specialized psychiatric care. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<p>It is not usually the first treatment choice for mild or uncomplicated depression.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_Happens_During_a_Treatment_Session\"><\/span>What Happens During a Treatment Session?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Esketamine is not typically used like an ordinary over-the-counter nasal spray. Treatment usually involves:<\/p>\n<ol>\n<li>\n<p>Evaluation by a qualified mental health professional.<\/p>\n<\/li>\n<li>\n<p>Administration of the nasal spray in a supervised healthcare setting.<\/p>\n<\/li>\n<li>\n<p>Monitoring for possible temporary reactions.<\/p>\n<\/li>\n<li>\n<p>Follow-up appointments to evaluate symptom improvement.<\/p>\n<\/li>\n<\/ol>\n<p>Medical supervision is important because some people may experience temporary dissociation, sedation, dizziness, or blood pressure changes after treatment. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 116px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">\u0627\u0644\u0645\u0643\u062a\u0628\u0629 \u0627\u0644\u0639\u0627\u0645\u0629 \u0644\u0644\u0637\u0628<\/span><\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Possible_Benefits_of_Fast-Acting_Depression_Nasal_Spray\"><\/span>Possible Benefits of Fast-Acting Depression Nasal Spray<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Potential advantages include:<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Rapid_symptom_improvement\"><\/span>Rapid symptom improvement<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Some patients experience mood improvements sooner than with many traditional antidepressants. This may be especially important when depression symptoms are severe. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 62px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">PubMed<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h3><span class=\"ez-toc-section\" id=\"A_different_treatment_pathway\"><\/span>A different treatment pathway<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Esketamine provides an alternative mechanism by targeting glutamate rather than primarily focusing on serotonin pathways.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Option_for_difficult-to-treat_depression\"><\/span>Option for difficult-to-treat depression<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>For individuals who have not responded sufficiently to multiple treatments, it offers another medically supervised option. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Side_Effects_and_Safety_Considerations\"><\/span>Side Effects and Safety Considerations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Although esketamine can be helpful, it requires careful monitoring. Possible short-term effects include:<\/p>\n<ul>\n<li>\n<p>Feeling detached from surroundings (dissociation)<\/p>\n<\/li>\n<li>\n<p>Sleepiness or sedation<\/p>\n<\/li>\n<li>\n<p>Dizziness<\/p>\n<\/li>\n<li>\n<p>Nausea<\/p>\n<\/li>\n<li>\n<p>Temporary increases in blood pressure<\/p>\n<\/li>\n<\/ul>\n<p>Because ketamine-related medications have potential misuse risks, treatment programs include safety controls and professional monitoring. <span class=\"\"><span class=\"ms-1 inline-flex max-w-full items-center select-none relative top-[-0.094rem] translate-y-0.5 animate-[show_150ms_ease-in]\" style=\"width: 77px;\"><span class=\"flex h-4.5 overflow-hidden rounded-xl pe-2 ps-1 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]! select-none\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\" style=\"opacity: 1; transform: none;\"><span class=\"flex min-w-0 flex-1 items-center gap-1\"><span class=\"inline-flex shrink-0 items-center justify-center overflow-hidden rounded-full\"><\/span><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">MedlinePlus<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Nasal_Spray_for_Depression_Compared_With_Traditional_Antidepressants\"><\/span>Nasal Spray for Depression Compared With Traditional Antidepressants<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Comparison<\/th><th class=\"last:pe-10\">Esketamine Nasal Spray<\/th><th class=\"last:pe-10\">Traditional Antidepressants<\/th><\/tr><\/thead><tbody><tr><td>Main pathway<\/td><td>Glutamate\/NMDA system<\/td><td>Often serotonin or norepinephrine<\/td><\/tr><tr><td>Speed<\/td><td>Faster onset for some patients<\/td><td>Usually several weeks<\/td><\/tr><tr><td>Use case<\/td><td>Often treatment-resistant depression<\/td><td>Broad range of depression conditions<\/td><\/tr><tr><td>Monitoring<\/td><td>Requires supervised administration<\/td><td>Usually taken independently at home<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 48.8906px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"Important_Medical_Considerations\"><\/span>Important Medical Considerations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Esketamine nasal spray should only be used according to a psychiatrist\u2019s treatment plan. Depression is a complex condition, and medication decisions depend on diagnosis, previous treatments, medical history, and safety considerations.<\/p>\n<p><strong>Medical Disclaimer:<\/strong><br>\nThe information in this article is for educational purposes only and does not replace advice from a qualified doctor or healthcare professional. Do not use this information to diagnose, treat, or change medication for any health condition. Always consult a medical professional before starting, stopping, or modifying any treatment.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nasal Spray for Depression: How Fast-Action Care Works Nasal spray for depression refers mainly to esketamine nasal spray, a prescription treatment designed for certain adults with treatment-resistant depression (TRD) and, in some cases, major depressive disorder with acute suicidal thoughts when used under medical supervision. Unlike traditional antidepressants that often take weeks, esketamine works through&#8230;<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[730],"tags":[],"class_list":["post-4119","post","type-post","status-publish","format-standard","hentry","category-depression"],"acf":[],"_links":{"self":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4119","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/comments?post=4119"}],"version-history":[{"count":2,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4119\/revisions"}],"predecessor-version":[{"id":5915,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4119\/revisions\/5915"}],"wp:attachment":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/media?parent=4119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/categories?post=4119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/tags?post=4119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}