{"id":4214,"date":"2026-09-05T17:03:44","date_gmt":"2026-09-05T14:03:44","guid":{"rendered":"https:\/\/wniss.com\/?p=4214"},"modified":"2026-09-05T17:04:36","modified_gmt":"2026-09-05T14:04:36","slug":"overview-of-tetracyclic-antidepressants-mechanisms-uses","status":"publish","type":"post","link":"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/","title":{"rendered":"Overview of Tetracyclic Antidepressants Mechanisms &#038; Uses"},"content":{"rendered":"<figure class=\"wch-inserted-image\"><img decoding=\"async\" width=\"1024\" height=\"684\" src=\"https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-1024x684.webp\" alt=\"Overview of Tetracyclic Antidepressants Mechanisms &amp; Uses - Overview of Tetracyclic Antidepressants Mechanisms\" loading=\"lazy\" class=\"wp-image-6040\" title=\"\" srcset=\"https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-1024x684.webp 1024w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-300x200.webp 300w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-150x100.webp 150w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-100x67.webp 100w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-200x134.webp 200w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-250x167.webp 250w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-350x234.webp 350w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-400x267.webp 400w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-500x334.webp 500w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1-600x401.webp 600w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-1-SB2mt1.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<div class=\"markdown prose dark:prose-invert wrap-break-word w-full light markdown-new-styling\"><h2><span class=\"ez-toc-section\" id=\"Overview_of_Tetracyclic_Antidepressants_Mechanisms_Uses\"><\/span>Overview of Tetracyclic Antidepressants Mechanisms &amp; Uses<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Quick_Answer_BLUF\"><\/span>Quick Answer (BLUF)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Tetracyclic antidepressants (TeCAs) are a class of antidepressant medications that treat major depressive disorder and certain anxiety-related conditions by affecting brain chemicals involved in mood regulation. Although they are prescribed less often than selective serotonin reuptake inhibitors (SSRIs), they remain valuable treatment options for selected patients, especially those experiencing insomnia, poor appetite, or intolerance to other antidepressants.<\/p><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Overview_of_Tetracyclic_Antidepressants_Mechanisms_Uses\" >Overview of Tetracyclic Antidepressants Mechanisms &amp; Uses<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Quick_Answer_BLUF\" >Quick Answer (BLUF)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#What_Are_Tetracyclic_Antidepressants\" >What Are Tetracyclic Antidepressants?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#How_Tetracyclic_Antidepressants_Work\" >How Tetracyclic Antidepressants Work<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Increasing_Norepinephrine_Activity\" >Increasing Norepinephrine Activity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Indirect_Effects_on_Serotonin\" >Indirect Effects on Serotonin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Histamine_Receptor_Blockade\" >Histamine Receptor Blockade<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Blocking_Specific_Serotonin_Receptors\" >Blocking Specific Serotonin Receptors<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Common_Tetracyclic_Antidepressants\" >Common Tetracyclic Antidepressants<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Mirtazapine\" >Mirtazapine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Maprotiline\" >Maprotiline<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Conditions_Treated_with_Tetracyclic_Antidepressants\" >Conditions Treated with Tetracyclic Antidepressants<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Major_Depressive_Disorder\" >Major Depressive Disorder<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Anxiety_Symptoms\" >Anxiety Symptoms<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Sleep_Disturbances\" >Sleep Disturbances<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Appetite_Loss\" >Appetite Loss<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Advantages_of_Tetracyclic_Antidepressants\" >Advantages of Tetracyclic Antidepressants<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Better_Sleep\" >Better Sleep<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Appetite_Improvement\" >Appetite Improvement<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Lower_Sexual_Side_Effects\" >Lower Sexual Side Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Useful_After_Other_Treatments_Fail\" >Useful After Other Treatments Fail<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Possible_Side_Effects\" >Possible Side Effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Less_Common_but_Serious_Risks\" >Less Common but Serious Risks<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Who_May_Benefit_Most\" >Who May Benefit Most?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Who_Should_Use_Them_Carefully\" >Who Should Use Them Carefully?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#How_Long_Do_They_Take_to_Work\" >How Long Do They Take to Work?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Tips_for_Safe_Use\" >Tips for Safe Use<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Lifestyle_Habits_That_Support_Recovery\" >Lifestyle Habits That Support Recovery<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Frequently_Asked_Questions\" >Frequently Asked Questions<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Are_tetracyclic_antidepressants_still_used_today\" >Are tetracyclic antidepressants still used today?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Is_mirtazapine_a_tetracyclic_antidepressant\" >Is mirtazapine a tetracyclic antidepressant?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Do_tetracyclic_antidepressants_cause_weight_gain\" >Do tetracyclic antidepressants cause weight gain?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#How_are_tetracyclic_antidepressants_different_from_SSRIs\" >How are tetracyclic antidepressants different from SSRIs?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Can_tetracyclic_antidepressants_be_stopped_suddenly\" >Can tetracyclic antidepressants be stopped suddenly?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Source\" >Source<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/wniss.com\/en-gb\/overview-of-tetracyclic-antidepressants-mechanisms-uses\/#Medical_Disclaimer\" >Medical Disclaimer<\/a><\/li><\/ul><\/nav><\/div>\n\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Feature<\/th><th class=\"last:pe-10\">Summary<\/th><\/tr><\/thead><tbody><tr><td>Drug Class<\/td><td>Tetracyclic antidepressants (TeCAs)<\/td><\/tr><tr><td>Primary Use<\/td><td>Major depressive disorder<\/td><\/tr><tr><td>Mechanism<\/td><td>Enhances norepinephrine and serotonin neurotransmission through receptor blockade<\/td><\/tr><tr><td>Common Medications<\/td><td>Mirtazapine, Maprotiline<\/td><\/tr><tr><td>Benefits<\/td><td>Improves mood, sleep, and appetite<\/td><\/tr><tr><td>Common Side Effects<\/td><td>Drowsiness, weight gain, dry mouth, dizziness<\/td><\/tr><tr><td>Time to Work<\/td><td>Usually 2\u20136 weeks<\/td><\/tr><tr><td>Prescription Required<\/td><td>Yes<\/td><\/tr><tr><td>Monitoring<\/td><td>Regular follow-up with a healthcare provider<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 32.7969px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_Are_Tetracyclic_Antidepressants\"><\/span>What Are Tetracyclic Antidepressants?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Tetracyclic antidepressants are prescription medications used to treat depression by changing the activity of neurotransmitters in the brain. Their chemical structure contains four interconnected rings, distinguishing them from tricyclic antidepressants, which have three.<\/p>\n<p>Although this medication class includes relatively few drugs, it offers unique advantages for people who struggle with depression accompanied by:<\/p>\n<ul>\n<li>\n<p>Insomnia<\/p>\n<\/li>\n<li>\n<p>Anxiety<\/p>\n<\/li>\n<li>\n<p>Reduced appetite<\/p>\n<\/li>\n<li>\n<p>Unintentional weight loss<\/p>\n<\/li>\n<\/ul>\n<p>Unlike many newer antidepressants, tetracyclic antidepressants often provide calming effects that may improve sleep while relieving depressive symptoms.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_Tetracyclic_Antidepressants_Work\"><\/span>How Tetracyclic Antidepressants Work<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The brain relies on neurotransmitters to regulate mood, emotions, motivation, and sleep. Depression is associated with altered signaling involving several neurotransmitters.<\/p>\n<p>Tetracyclic antidepressants work through multiple receptor actions rather than targeting only one neurotransmitter.<\/p>\n<p>Their mechanisms may include:<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Increasing_Norepinephrine_Activity\"><\/span>Increasing Norepinephrine Activity<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Most tetracyclic antidepressants increase norepinephrine availability, improving:<\/p>\n<ul>\n<li>\n<p>Energy<\/p>\n<\/li>\n<li>\n<p>Motivation<\/p>\n<\/li>\n<li>\n<p>Concentration<\/p>\n<\/li>\n<li>\n<p>Alertness<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Indirect_Effects_on_Serotonin\"><\/span>Indirect Effects on Serotonin<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Some medications, especially mirtazapine, increase serotonin release indirectly by blocking alpha-2 adrenergic receptors.<\/p>\n<p>Rather than preventing serotonin reuptake like SSRIs, they encourage greater serotonin signaling while selectively enhancing receptors associated with mood improvement.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Histamine_Receptor_Blockade\"><\/span>Histamine Receptor Blockade<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Many tetracyclic antidepressants strongly block histamine H1 receptors.<\/p>\n<p>This action contributes to:<\/p>\n<ul>\n<li>\n<p>Better sleep<\/p>\n<\/li>\n<li>\n<p>Reduced anxiety<\/p>\n<\/li>\n<li>\n<p>Sedation<\/p>\n<\/li>\n<\/ul>\n<p>However, it also explains why drowsiness is one of the most common side effects.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Blocking_Specific_Serotonin_Receptors\"><\/span>Blocking Specific Serotonin Receptors<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Certain TeCAs block serotonin receptors linked to nausea, insomnia, and sexual dysfunction.<\/p>\n<p>Because of this mechanism, some patients experience fewer sexual side effects compared with SSRIs.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Common_Tetracyclic_Antidepressants\"><\/span>Common Tetracyclic Antidepressants<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Mirtazapine\"><\/span>Mirtazapine<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Mirtazapine is currently the most widely prescribed tetracyclic antidepressant.<\/p>\n<p>Common uses include:<\/p>\n<ul>\n<li>\n<p>Major depressive disorder<\/p>\n<\/li>\n<li>\n<p>Depression with insomnia<\/p>\n<\/li>\n<li>\n<p>Depression associated with weight loss<\/p>\n<\/li>\n<li>\n<p>Anxiety symptoms<\/p>\n<\/li>\n<li>\n<p>Poor appetite<\/p>\n<\/li>\n<\/ul>\n<p>It is frequently chosen when improving sleep and nutrition is an important treatment goal.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Maprotiline\"><\/span>Maprotiline<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Maprotiline mainly increases norepinephrine activity.<\/p>\n<p>Although effective, it is prescribed less frequently today because safer alternatives are available and it carries a higher seizure risk than many newer antidepressants.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Conditions_Treated_with_Tetracyclic_Antidepressants\"><\/span>Conditions Treated with Tetracyclic Antidepressants<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Healthcare providers may prescribe tetracyclic antidepressants for several conditions.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Major_Depressive_Disorder\"><\/span>Major Depressive Disorder<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Their primary approved use is treating major depression, particularly when symptoms include:<\/p>\n<ul>\n<li>\n<p>Persistent sadness<\/p>\n<\/li>\n<li>\n<p>Low motivation<\/p>\n<\/li>\n<li>\n<p>Sleep disturbance<\/p>\n<\/li>\n<li>\n<p>Appetite changes<\/p>\n<\/li>\n<li>\n<p>Anxiety<\/p>\n<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Anxiety_Symptoms\"><\/span>Anxiety Symptoms<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Some patients experience improvements in generalized anxiety symptoms due to the calming properties of these medications.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Sleep_Disturbances\"><\/span>Sleep Disturbances<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Sedating tetracyclic antidepressants may help patients whose depression is accompanied by chronic insomnia.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Appetite_Loss\"><\/span>Appetite Loss<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Mirtazapine frequently increases appetite, making it useful for individuals experiencing significant weight loss during depression.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Advantages_of_Tetracyclic_Antidepressants\"><\/span>Advantages of Tetracyclic Antidepressants<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Several characteristics make these medications valuable despite newer treatment options.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Better_Sleep\"><\/span>Better Sleep<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Unlike activating antidepressants, many TeCAs improve sleep quality from the beginning of treatment.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Appetite_Improvement\"><\/span>Appetite Improvement<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Patients with poor appetite often regain healthy eating habits after treatment begins.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Lower_Sexual_Side_Effects\"><\/span>Lower Sexual Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Compared with SSRIs, mirtazapine generally causes fewer sexual adverse effects.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Useful_After_Other_Treatments_Fail\"><\/span>Useful After Other Treatments Fail<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Doctors sometimes recommend tetracyclic antidepressants when:<\/p>\n<ul>\n<li>\n<p>SSRIs are ineffective<\/p>\n<\/li>\n<li>\n<p>SNRIs cause unacceptable side effects<\/p>\n<\/li>\n<li>\n<p>Additional sleep support is needed<\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Possible_Side_Effects\"><\/span>Possible Side Effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Like all antidepressants, tetracyclic antidepressants may cause adverse effects.<\/p>\n<p>Common side effects include:<\/p>\n<ul>\n<li>\n<p>Sleepiness<\/p>\n<\/li>\n<li>\n<p>Increased appetite<\/p>\n<\/li>\n<li>\n<p>Weight gain<\/p>\n<\/li>\n<li>\n<p>Dry mouth<\/p>\n<\/li>\n<li>\n<p>Constipation<\/p>\n<\/li>\n<li>\n<p>Dizziness<\/p>\n<\/li>\n<li>\n<p>Fatigue<\/p>\n<\/li>\n<\/ul>\n<p>Many side effects improve after several weeks as the body adjusts.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Less_Common_but_Serious_Risks\"><\/span>Less Common but Serious Risks<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Although uncommon, serious complications require prompt medical attention.<\/p>\n<p>These may include:<\/p>\n<ul>\n<li>\n<p>Severe allergic reactions<\/p>\n<\/li>\n<li>\n<p>Confusion<\/p>\n<\/li>\n<li>\n<p>Irregular heartbeat<\/p>\n<\/li>\n<li>\n<p>Seizures (especially with maprotiline)<\/p>\n<\/li>\n<li>\n<p>Suicidal thoughts in younger patients during early treatment<\/p>\n<\/li>\n<\/ul>\n<p>Any worsening depression or suicidal thinking should be reported immediately to a healthcare provider.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Who_May_Benefit_Most\"><\/span>Who May Benefit Most?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Tetracyclic antidepressants are often considered for adults experiencing depression together with:<\/p>\n<ul>\n<li>\n<p>Chronic insomnia<\/p>\n<\/li>\n<li>\n<p>Significant weight loss<\/p>\n<\/li>\n<li>\n<p>Reduced appetite<\/p>\n<\/li>\n<li>\n<p>Anxiety symptoms<\/p>\n<\/li>\n<li>\n<p>Poor tolerance of SSRIs<\/p>\n<\/li>\n<\/ul>\n<p>They are not automatically the best first-choice medication for everyone.<\/p>\n<p>Treatment decisions depend on:<\/p>\n<ul>\n<li>\n<p>Medical history<\/p>\n<\/li>\n<li>\n<p>Current medications<\/p>\n<\/li>\n<li>\n<p>Age<\/p>\n<\/li>\n<li>\n<p>Existing health conditions<\/p>\n<\/li>\n<li>\n<p>Individual side-effect preferences<\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Who_Should_Use_Them_Carefully\"><\/span>Who Should Use Them Carefully?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Healthcare providers may recommend extra caution for individuals with:<\/p>\n<ul>\n<li>\n<p>Epilepsy<\/p>\n<\/li>\n<li>\n<p>Severe liver disease<\/p>\n<\/li>\n<li>\n<p>Bipolar disorder<\/p>\n<\/li>\n<li>\n<p>Heart rhythm disorders<\/p>\n<\/li>\n<li>\n<p>Glaucoma<\/p>\n<\/li>\n<li>\n<p>Older age with increased fall risk<\/p>\n<\/li>\n<\/ul>\n<p>Medication interactions should always be reviewed before starting treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_Long_Do_They_Take_to_Work\"><\/span>How Long Do They Take to Work?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Most people notice gradual improvement.<\/p>\n<p>Typical timeline:<\/p>\n<div class=\"TyagGW_tableContainer\"><div tabindex=\"-1\" class=\"group TyagGW_tableWrapper flex flex-col-reverse w-fit\"><table class=\"w-fit min-w-(--thread-content-width)\"><thead><tr><th class=\"last:pe-10\">Time<\/th><th class=\"last:pe-10\">Expected Changes<\/th><\/tr><\/thead><tbody><tr><td>Week 1<\/td><td>Better sleep, mild appetite improvement<\/td><\/tr><tr><td>Weeks 2\u20134<\/td><td>Reduced anxiety and improved energy<\/td><\/tr><tr><td>Weeks 4\u20136<\/td><td>Noticeable improvement in mood<\/td><\/tr><tr><td>Weeks 6\u20138<\/td><td>Full therapeutic response for many patients<\/td><\/tr><\/tbody><\/table><div class=\"relative h-0 self-end select-none\"><div class=\"absolute end-0 flex items-end\" style=\"height: 32.7969px;\"><span class=\"\"><button aria-label=\"\u0646\u0633\u062e \u0627\u0644\u062c\u062f\u0648\u0644\" class=\"hover:bg-token-bg-tertiary text-token-text-secondary relative z-10 my-1 rounded-sm p-1 transition-opacity group-[:not(:hover):not(:focus-within)]:pointer-events-none group-[:not(:hover):not(:focus-within)]:opacity-0\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"icon\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#ce3544\" fill=\"currentColor\"><\/use><\/svg><\/button><\/span><\/div><\/div><\/div><\/div>\n<p>Patients should continue taking medication exactly as prescribed, even if improvements appear gradually.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Tips_for_Safe_Use\"><\/span>Tips for Safe Use<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Successful treatment involves more than taking medication.<\/p>\n<p>Helpful recommendations include:<\/p>\n<ul>\n<li>\n<p>Take medication at the same time every day.<\/p>\n<\/li>\n<li>\n<p>Avoid stopping treatment suddenly.<\/p>\n<\/li>\n<li>\n<p>Attend regular follow-up appointments.<\/p>\n<\/li>\n<li>\n<p>Report unusual symptoms promptly.<\/p>\n<\/li>\n<li>\n<p>Avoid alcohol unless approved by your healthcare provider.<\/p>\n<\/li>\n<li>\n<p>Discuss all prescription and over-the-counter medications before combining them.<\/p>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"Lifestyle_Habits_That_Support_Recovery\"><\/span>Lifestyle Habits That Support Recovery<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Medication often works best alongside healthy daily habits.<\/p>\n<p>These include:<\/p>\n<ul>\n<li>\n<p>Regular physical activity<\/p>\n<\/li>\n<li>\n<p>Consistent sleep schedules<\/p>\n<\/li>\n<li>\n<p>Balanced nutrition<\/p>\n<\/li>\n<li>\n<p>Stress management techniques<\/p>\n<\/li>\n<li>\n<p>Social support<\/p>\n<\/li>\n<li>\n<p>Professional psychotherapy when appropriate<\/p>\n<\/li>\n<\/ul>\n<p>Combining medication with psychological therapy frequently leads to better long-term outcomes than either approach alone.<\/p>\n<blockquote>\n<p><strong>Internal Linking Opportunity:<\/strong> Learn more about depression symptoms and treatment options by linking naturally to:<\/p>\n<ul>\n<li>\n<p><span class=\"decorated-link\">https:\/\/wniss.com\/en-gb\/depression\/<span aria-hidden=\"true\" class=\"ms-0.5 inline-block align-middle leading-none select-none\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"block h-[0.75em] w-[0.75em] stroke-current stroke-[0.75] select-none\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#304883\" fill=\"currentColor\"><\/use><\/svg><\/span><\/span><\/p>\n<\/li>\n<li>\n<p><span class=\"decorated-link\">https:\/\/wniss.com\/en-gb\/category\/depression\/<span aria-hidden=\"true\" class=\"ms-0.5 inline-block align-middle leading-none select-none\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"block h-[0.75em] w-[0.75em] stroke-current stroke-[0.75] select-none\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#304883\" fill=\"currentColor\"><\/use><\/svg><\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/blockquote>\n<h2><span class=\"ez-toc-section\" id=\"Frequently_Asked_Questions\"><\/span>Frequently Asked Questions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<h3><span class=\"ez-toc-section\" id=\"Are_tetracyclic_antidepressants_still_used_today\"><\/span>Are tetracyclic antidepressants still used today?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Yes. Although they are prescribed less frequently than SSRIs and SNRIs, medications like mirtazapine remain widely used because of their effectiveness for depression with insomnia or poor appetite.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Is_mirtazapine_a_tetracyclic_antidepressant\"><\/span>Is mirtazapine a tetracyclic antidepressant?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Yes. Mirtazapine is the best-known and most commonly prescribed tetracyclic antidepressant.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Do_tetracyclic_antidepressants_cause_weight_gain\"><\/span>Do tetracyclic antidepressants cause weight gain?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Some patients experience increased appetite and weight gain, particularly with mirtazapine. The degree varies among individuals.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_are_tetracyclic_antidepressants_different_from_SSRIs\"><\/span>How are tetracyclic antidepressants different from SSRIs?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>SSRIs primarily block serotonin reuptake, while tetracyclic antidepressants work through multiple receptor mechanisms involving norepinephrine, serotonin, and histamine pathways.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Can_tetracyclic_antidepressants_be_stopped_suddenly\"><\/span>Can tetracyclic antidepressants be stopped suddenly?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>No. Abrupt discontinuation may lead to withdrawal symptoms. Any medication changes should be supervised by a healthcare provider.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Source\"><\/span>Source<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><span class=\"decorated-link\">https:\/\/en.wikipedia.org\/wiki\/Depression_(mood)<span aria-hidden=\"true\" class=\"ms-0.5 inline-block align-middle leading-none select-none\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"20\" height=\"20\" aria-hidden=\"true\" class=\"block h-[0.75em] w-[0.75em] stroke-current stroke-[0.75] select-none\"><use href=\"\/cdn\/assets\/sprites-core-18ad762e.svg#304883\" fill=\"currentColor\"><\/use><\/svg><\/span><\/span><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Medical_Disclaimer\"><\/span>Medical Disclaimer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The information provided in this article is for educational and informational purposes only and should not replace professional medical advice, diagnosis, or treatment. Do not rely on this content to diagnose or treat any medical condition. Always consult a qualified physician or healthcare provider before starting, stopping, or changing any medication or treatment plan.<\/p><\/div>\n<figure class=\"wch-inserted-image\"><img decoding=\"async\" width=\"1024\" height=\"668\" src=\"https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-1024x668.webp\" alt=\"Overview of Tetracyclic Antidepressants Mechanisms &amp; Uses - Overview of Tetracyclic Antidepressants Mechanisms\" loading=\"lazy\" class=\"wp-image-6041\" title=\"\" srcset=\"https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-1024x668.webp 1024w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-300x196.webp 300w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-150x98.webp 150w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-100x65.webp 100w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-200x131.webp 200w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-250x163.webp 250w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-350x228.webp 350w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-400x261.webp 400w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-500x326.webp 500w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4-600x392.webp 600w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-2-36LnW4.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><figure class=\"wch-inserted-image\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-1024x576.webp\" alt=\"Overview of Tetracyclic Antidepressants Mechanisms &amp; Uses - Overview of Tetracyclic Antidepressants Mechanisms\" loading=\"lazy\" class=\"wp-image-6042\" title=\"\" srcset=\"https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-1024x576.webp 1024w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-300x169.webp 300w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-150x84.webp 150w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-100x56.webp 100w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-200x113.webp 200w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-250x141.webp 250w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-350x197.webp 350w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-400x225.webp 400w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-500x281.webp 500w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn-600x338.webp 600w, https:\/\/wniss.com\/wp-content\/uploads\/2026\/09\/overview-of-tetracyclic-antidepressants-mechanisms-uses-3-h5YNvn.webp 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>","protected":false},"excerpt":{"rendered":"<p>Overview of Tetracyclic Antidepressants Mechanisms &amp; Uses Quick Answer (BLUF) Tetracyclic antidepressants (TeCAs) are a class of antidepressant medications that treat major depressive disorder and certain anxiety-related conditions by affecting brain chemicals involved in mood regulation. Although they are prescribed less often than selective serotonin reuptake inhibitors (SSRIs), they remain valuable treatment options for selected&#8230;<\/p>\n","protected":false},"author":11,"featured_media":6040,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[730],"tags":[],"class_list":["post-4214","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-depression"],"acf":[],"_links":{"self":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4214","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/comments?post=4214"}],"version-history":[{"count":2,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4214\/revisions"}],"predecessor-version":[{"id":6043,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/posts\/4214\/revisions\/6043"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/media\/6040"}],"wp:attachment":[{"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/media?parent=4214"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/categories?post=4214"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wniss.com\/en-gb\/wp-json\/wp\/v2\/tags?post=4214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}